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Postmenopausal hormone therapy and mortality

Authors :
Grodstein, Francine
Stampfer, Meir J.
Colditz, Graham A.
Willett, Walter C.
Manson, Joann E.
Joffe, Marshall
Rosner, Bernard
Fuchs, Charles
Hankinson, Susan E.
Hunter, David J.
Hennekens, Charles H.
Speizer, Frank E.
Source :
The New England Journal of Medicine. June 19, 1997, Vol. v336 Issue n25, p1769, 7 p.
Publication Year :
1997

Abstract

Estrogen replacement therapy does not appear to significantly reduce mortality rates from heart disease in women who have a low risk of the disease. This is one of the conclusions of the Nurses' Health Study, which has followed 121,700 female nurses since 1976. By 1994, 3,637 had died. Those who used estrogen replacement therapy had a lower risk of death compared to those who never had. However, the increased risk of breast cancer in hormone users reduced that benefit over time. Hormone users with risk factors for heart disease benefitted the most, whereas those without risk factors benefitted little.

Details

ISSN :
00284793
Volume :
v336
Issue :
n25
Database :
Gale General OneFile
Journal :
The New England Journal of Medicine
Publication Type :
Academic Journal
Accession number :
edsgcl.19538650