Quantitative aspects of interorgan relationships among arginine and citrulline metabolism

A stable isotope tracer arteriovenous difference protocol was utilized to determine the kinetic mechanisms of whole body arginine and citrulline metabolism in the kidneys and splanchnic region. Analysis of arginine and citrulline metabolism in chronic multicatheritized dog models indicated a higher rate of arginine uptake in the liver compared to the intestines. Furthermore, citrulline from the liver and intestines are converted into arginine in the kidneys and intestines.