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Translational control of the innate immune response through IRF-7

Authors :
Colina, Rodney
Costa-Mattioli, Mauro
Dowling, Ryan J.O.
Jaramillo, Maritza
Tai, Lee-Hwa
Breitbach, Caroline J.
Martineau, Yvan
Larsson, Ola
Rong, Liwei
Svitkin, Yuri V.
Makrigiannis, Andrew P.
Bell, John C.
Sonenberg, Nahum
Source :
Nature. March 20, 2008, Vol. 452 Issue 7185, p323, 7 p.
Publication Year :
2008

Abstract

Transcriptional activation of cytokines, such as type-I interferons (interferon (IFN)-α and IFN-β), constitutes the first line of antiviral defence. Here we show that translational control is critical for induction of [...]

Subjects

Subjects :
Interferon -- Physiological aspects -- Genetic aspects -- Research
Genetic translation -- Research -- Genetic aspects -- Physiological aspects
Immune response -- Physiological aspects -- Genetic aspects -- Research
Environmental issues
Science and technology
Zoology and wildlife conservation
Physiological aspects
Genetic aspects
Research

Details

Language :
English
ISSN :
00280836
Volume :
452
Issue :
7185
Database :
Gale General OneFile
Journal :
Nature
Publication Type :
Academic Journal
Accession number :
edsgcl.193473928

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