Carbapenems and SHV-1 [beta]-lactamase form different acyl-enzyme populations in crystals and solution

Authors :: Kalp, Matthew
Carey, Paul R.
Source :: Biochemistry. Nov 11, 2008, Vol. 47 Issue 45, 11830-11837
Publication Year :: 2008
Abstract: Raman microscopy is used for studying the reactions between single crystals of the SHV-1 [beta]-lactamase enzyme and the carbapenems, meropenem, imipenem and ertapenem. The studies have shown that mechanism-based inhibitors like carbapenems have behaved differently in the crystalline and solution phase of the SHV-1 [beta]-lactamase.

Subjects :: Beta lactam antibiotics -- Structure
Beta lactam antibiotics -- Properties
Beta lactam antibiotics -- Research
Beta lactamases -- Structure
Beta lactamases -- Physiological aspects
Beta lactamases -- Research
Raman spectroscopy -- Usage
Biological sciences
Chemistry

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