Extracellular glucose distribution is not altered by insulin: analysis of plasma and interstitial L-glucose kinetics

The effect of insulin on whole body glucose distribution kinetics was investigated in anesthetized dogs. Whole body kinetic analysis of plasma L-glucose was performed using a three- or four-compartment model. Lymph L-glucose data were compared with the results of plasma L-glucose analysis. Data indicated that insulin does not affect whole body glucose distribution. Glucose dynamics were best predicted by a four-compartment model.