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Total synthesis and proof of structure of a human breast tumor (globo-H) antigen
- Source :
- Journal of the American Chemical Society. Nov 20, 1996, Vol. 118 Issue 46, p11488, 13 p.
- Publication Year :
- 1996
-
Abstract
- A total synthesis of the Hakomori MBr1 antigen, heavily expressed on human breast tumors, was performed. The construction required the assembly of four glycals and an L-fucose derivative. The sensitivity of the stereochemistry of sulfonamido galactosylation by a terminal galactose ring as a function of the state of protection status of its C4 alcohol was exploited in a crucial step. A linker domain was established for the purpose of developing a functional vaccine.
- Subjects :
- Tumor antigens -- Research
Breast tumors -- Research
Chemistry
Subjects
Details
- ISSN :
- 00027863
- Volume :
- 118
- Issue :
- 46
- Database :
- Gale General OneFile
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.18997468