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Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway

Authors :
John, Matthias
Constien, Rainer
Akinc, Akin
Goldberg, Michael
Moons, Young-Ah
Spranger, Martina
Hadwiger, Philipp
Soutschek, Jurgen
Vornlocher, Hans-Peter
Manoharan, Muthiah
Stoffel, Markus
Langer, Robert
Anderson, Daniel G.
Horton, Jay D.
Koteliansky, Victor
Bumcrot, David
Source :
Nature. Oct 11, 2007, Vol. 449 Issue 7163, p745, 4 p.
Publication Year :
2007

Abstract

Systemic administration of synthetic small interfering RNAs (siRNAs) effectively silences hepatocyte gene expression in rodents and primates (1-3). Whether or not in vivo gene silencing by synthetic siRNA can disrupt [...]

Details

Language :
English
ISSN :
00280836
Volume :
449
Issue :
7163
Database :
Gale General OneFile
Journal :
Nature
Publication Type :
Academic Journal
Accession number :
edsgcl.189748697