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Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosamINNglycans
Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosamINNglycans
- Source :
- Nature. Oct 10, 1996, Vol. 383 Issue 6600, p550, 4 p.
- Publication Year :
- 1996
-
Abstract
- Sulphated glycosamINNglycans such as heparin induce tau under physiological conditions in vitro to form paired helical filaments (PHFs), composed of the microtubule-associated protein tau in a hyperphosphorylated state. PHFs are the major component of neurofibrillary deposits that constitute a defining neuropathological feature of Alzheimer's disease. Heparin also inhibits tau from binding to microtubules, leading to microtubule disassembly. Furthermore, heparan sulphate is found with tau in affected regions of the brain at the earliest stages of Alzheimer's disease.
Details
- ISSN :
- 00280836
- Volume :
- 383
- Issue :
- 6600
- Database :
- Gale General OneFile
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.18930657