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Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosamINNglycans

Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosamINNglycans

Authors :
Goedert, M.
Jakes, R.
Spillantini, M.G.
Hasegawa, M.
Smith, M.J.
Crowther, R.A.
Source :
Nature. Oct 10, 1996, Vol. 383 Issue 6600, p550, 4 p.
Publication Year :
1996

Abstract

Sulphated glycosamINNglycans such as heparin induce tau under physiological conditions in vitro to form paired helical filaments (PHFs), composed of the microtubule-associated protein tau in a hyperphosphorylated state. PHFs are the major component of neurofibrillary deposits that constitute a defining neuropathological feature of Alzheimer's disease. Heparin also inhibits tau from binding to microtubules, leading to microtubule disassembly. Furthermore, heparan sulphate is found with tau in affected regions of the brain at the earliest stages of Alzheimer's disease.

Details

ISSN :
00280836
Volume :
383
Issue :
6600
Database :
Gale General OneFile
Journal :
Nature
Publication Type :
Academic Journal
Accession number :
edsgcl.18930657