Growth hormone upregulates gastrin and peptide YY gene expression

The genetic basis of gastrin and peptide YY (PYY) synthesis in transgenic mice that overexpress growth hormone (GH) was investigated by biochemical and molecular techniques. GH transgenic mice had greater gastrin and PYY mRNA levels than wild-type mice in the antrum, ileum and colon, with highest mRNA expression in the ileum and colon. Since those increases are not related to food take, it was suggested that gastrin and PYY gene expression could be regulated by GH or insulin-like growth factor I.