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No evidence for a role of reverse Na+-Ca2+ exchange in insulin release from mouse pancreatic islets
- Source :
- The American Journal of Physiology. Sept, 1996, Vol. 271 Issue 3, pE426, 8 p.
- Publication Year :
- 1996
-
Abstract
- The role of calcium (Ca2+) currents in the initiation of insulin secretion in intact mouse pancreatic islets is investigated based on measurements of insulin release, cytoplasmic calcium concentration and B cell membrane potential. Data indicate that Ca2+ influx via reverse Na+-Ca2+ exchange has no effect on cytoplasmic calcium concentration. However, Ca2+ influx via voltage-dependent Ca2+ channels promote insulin release by increasing cytoplasmic calcium levels through removal of Na+.
Details
- ISSN :
- 00029513
- Volume :
- 271
- Issue :
- 3
- Database :
- Gale General OneFile
- Journal :
- The American Journal of Physiology
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.18890852