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Solution conformation of the (-)-cis-anti-Benzo(a)pyrenyl-dG adduct opposite dC in a DNA duplex: intercalation of the covalently attached BP ring into the helix with base displacement of the modified deoxyguanosine into the major groove
- Source :
- Biochemistry. July 30, 1996, Vol. 35 Issue 30, p9850, 14 p.
- Publication Year :
- 1996
-
Abstract
- The covalently attached Benzo(a)pyrenyl ring (BP) intercalates between the dC5.dG18 and dC7.dG16 base pairs of the DNA duplex molecule and displaces deoxyguanosine (BP)-dG6 and its partner cytosine dC17 from the helix into the major groove. The benzylic ring in the intercalated BP ring is oriented towards the minor groove in the (+)cis-anti-(BP)dG.dC duplex isomer and towards the major groove in the (-)cis-anti isomer. Both duplex adducts displace the modified deoxyguanosine into the major groove.
Details
- ISSN :
- 00062960
- Volume :
- 35
- Issue :
- 30
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.18834450