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Impairment of phagosome-lysosome fusion in HIV-1-infected macrophages

Authors :
Moorjani, Harish
Craddock, Barbara P.
Morrison, Sidonie A.
Steigbigel, Roy T.
Source :
Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. Sept, 1996, Vol. 13 Issue 1, p18, 7 p.
Publication Year :
1996

Abstract

People infected with HIV-1 may be more susceptible to opportunistic infections when phagosome-lysosome fusion is prevented in macrophages in their blood. Phagosome-lysosome fusion is necessary for the destruction of organisms and is suppressed by some viruses. Macrophages infected in vitro with HIV-1 showed a reduction in phagosome-lysosome fusion from an average of 70% to an average of 47%. The interaction of the two glycoproteins gp 120 and CD4 is the first step in viral entry and may be the cause of abnormal phagosome-lysosome fusion.

Details

ISSN :
10779450
Volume :
13
Issue :
1
Database :
Gale General OneFile
Journal :
Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Publication Type :
Periodical
Accession number :
edsgcl.18740721