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Impairment of phagosome-lysosome fusion in HIV-1-infected macrophages
- Source :
- Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. Sept, 1996, Vol. 13 Issue 1, p18, 7 p.
- Publication Year :
- 1996
-
Abstract
- People infected with HIV-1 may be more susceptible to opportunistic infections when phagosome-lysosome fusion is prevented in macrophages in their blood. Phagosome-lysosome fusion is necessary for the destruction of organisms and is suppressed by some viruses. Macrophages infected in vitro with HIV-1 showed a reduction in phagosome-lysosome fusion from an average of 70% to an average of 47%. The interaction of the two glycoproteins gp 120 and CD4 is the first step in viral entry and may be the cause of abnormal phagosome-lysosome fusion.
Details
- ISSN :
- 10779450
- Volume :
- 13
- Issue :
- 1
- Database :
- Gale General OneFile
- Journal :
- Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
- Publication Type :
- Periodical
- Accession number :
- edsgcl.18740721