Angiotensin II type 1 receptor modulation of neuronal K+ and Ca2+ currents: intracellular mechanisms

An investigation of voltage-dependent potassium and calcium conductance elicited by angiotensin II (ANG II) in neurons isolated from Sprague-Dawley rats showed that protein kinase C (PKC) and inositol 1,4,5-triphosphate (IP3) play an important role in the modulation of these ion currents after ANG II type 1 receptor activation. Addition of PKC antagonists further enhanced the ANG II-induced decrease in K+ current and abolished the ANG II-induced increase in Ca2+ current, whereas addition of IP3 reduced K+ current.