PI-3K/Akt pathway-dependent cyclin D1 expression is responsible for arsenite-induced human keratinocyte transformation

Authors :: Ouyang, Weiming
Luo, Wenjing
Zhang, Dongyun
Jian, Jinlong
Ma, Qian
Li, Jingxia
Shi, Xianglin
Chen, Jingyuan
Gao, Jimin
Huang, Chuanshu
Source :: Environmental Health Perspectives. Jan, 2008, Vol. 116 Issue 1, p1, 6 p.
Publication Year :: 2008
Abstract: BACKGROUNG: Long-term exposure of arsenite leads to human skin cancer. However, the exact mechanisms of arsenite-induced human skin carcinogenesis remain to be defined. OBJECTIVES: In this study, we investigated the [...]

Subjects :: Cell proliferation -- Analysis
Cell transformation -- Analysis
Arsenic compounds -- Health aspects
Arsenic compounds -- Research
Skin cancer -- Research
Skin cancer -- Development and progression
Skin cancer -- Risk factors

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