Effects of hypercapnia on prostanoid and cAMP production by cerebral microvascular cell cultures

The effects of hypercapnia on the formation of prostanoids and adenine 3',5'-cyclic monophosphate (cAMP) by cerebral microvascular cells were investigated in a cell model. Newborn pig cerebral microvascular smooth muscle cells and endothelial cells responded to hypercapnia by increasing prostanoid and cAMP production. This response is suggested to follow a prostanoid independent and an endothelium-dependent pathway.