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Functional and biophysical analysis of the C-terminus of the CGRP-receptor: a family B GPCR
- Source :
- Biochemistry. August 12, 2008, Vol. 47 Issue 32, 8434-8444
- Publication Year :
- 2008
-
Abstract
- The functional and biophysical studies on a peptide mimetic of the C-terminus of a family B GPCR (G-protein coupled receptor) domain that readily forms a membrane-parallel helix anchored to the liposome by an interfacial tryptophan residue are presented. The results reveal two key functions held within the C-terminus of a family B GPCR, which support an eighth helical region with striking topological similarity to the nonhomologous family A receptor.
Details
- Language :
- English
- ISSN :
- 00062960
- Volume :
- 47
- Issue :
- 32
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.183746253