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NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

Authors :
Rius, Jordi
Guma, Monica
Schachtrup, Christian
Akassoglou, Katerina
Zinkernagel, Annelies S.
Nizet, Victor
Johnson, Randall S.
Haddad, Gabriel G.
Karin, Michael
Source :
Nature. June 5, 2008, Vol. 453 Issue 7196, p807, 6 p.
Publication Year :
2008

Abstract

The hypoxic response is an ancient stress response triggered by low ambient oxygen ([O.sub.2]) (ref. 1) and controlled by hypoxia-inducible transcription factor-1 (HIF-1), whose a subunit is rapidly degraded under [...]

Details

Language :
English
ISSN :
00280836
Volume :
453
Issue :
7196
Database :
Gale General OneFile
Journal :
Nature
Publication Type :
Academic Journal
Accession number :
edsgcl.183424268