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Nuclear HuR accumulation through phosphorylation by Cdk1

Authors :
Hyeon Ho Kim
Abdelmohsen, Kotb
Lal, Ashish
Pullmann, Rudolf
Xiaoling Yang
Galban, Stefanie
Srikantan, Subramanya
Martindale, Jennifer L.
Blethrow, Justin
Shokat, Kevan M.
Gorospe, Myriam
Source :
Genes & Development. July 1, 2008, Vol. 22 Issue 13, 1804-1815
Publication Year :
2008

Abstract

Study conducted shows that HuR phosphorylation at S202 by the G2-phase kinase Cdk1 influences its subcellular distribution. Findings suggest that Cdk1 phosphorylates HuR post-transcriptional function and anti-apototic influence.

Details

Language :
English
ISSN :
08909369
Volume :
22
Issue :
13
Database :
Gale General OneFile
Journal :
Genes & Development
Publication Type :
Academic Journal
Accession number :
edsgcl.183275763