Agrobacterium-mediated disruption of a nonribosomal peptide synthetase gene in the invertebrate pathogen Metarhizium anisopliae reveals a peptide spore factor

Authors :: Yong-Sun Moon
Donzelli, Bruno G.G.
Krasnoff, Stuart B.
McLane, Heather
Griggs, Mike H.
Cooke, Peter
Vandenberg, John D.
Gibson, Donna M.
Churchill, Alice C.L.
Source :: Applied and Environmental Microbiology. July, 2008, Vol. 74 Issue 13-14, 4366-4380
Publication Year :: 2008
Abstract: The first targeted disruption of a secondary metabolite gene in Metarhizium anisopliae by Agrobacterium tumefaciens-mediated transformation (ATMT) is reported. The disruption facilitated the discovery of a new class of nonribosomal cyclic peptides called serinocyclins spore factor.

Subjects :: Agrobacterium tumefaciens -- Genetic aspects
Invertebrates -- Genetic aspects
Peptides -- Chemical properties
Biological sciences

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