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Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

Authors :
Meydan, Naftaly
Grunberger, Tom
Dadi, Harjit
Shahar, Michal
Arpaia, Enrico
Lapidot, Zvi
Leeder, J. Steven
Freedman, Melvin
Cohen, Amos
Gazit, Aviv
Levitzki, Alexander
Roifman, Chaim M.
Source :
Nature. Feb 15, 1996, Vol. 379 Issue 6566, p645, 4 p.
Publication Year :
1996

Abstract

The tyrphostin AG-490 suppresses acute lymphoblastic leukaemia cells by inactivating the Jak-2 protein tyrosine kinase (PTK). AG-490 inhibits cell growth by causing programmed cell deaths of the leukemia cells. Normal hematopoiesis is unaffected by AG-490. The Jak-2 PTK is active in leukemia cell lines and the patients of leukemia in relapse and is probably necessary for the growth of leukemia cells.

Subjects

Subjects :
Lymphocytic leukemia -- Research
Enzyme inhibitors -- Physiological aspects
Cell death -- Observations
Environmental issues
Science and technology
Zoology and wildlife conservation

Details

ISSN :
00280836
Volume :
379
Issue :
6566
Database :
Gale General OneFile
Journal :
Nature
Publication Type :
Academic Journal
Accession number :
edsgcl.18210771

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