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Binding to protein targets of peptidic leads discovered by phage display: crystal structures of streptavidin-bound linear and cyclic peptide ligands containing the HPQ sequence
- Source :
- Biochemistry. Nov 28, 1995, Vol. 34 Issue 47, p15421, 9 p.
- Publication Year :
- 1995
-
Abstract
- The binding interactions of streptavidin with linear and cyclic peptides incorporate direct H-bonds, hydrophobic interactions and H-bonds due to water molecules. The linear and disulfide-bridged cyclic peptides have a conserved tripeptide sequence, HPQ. Cyclic peptides containing HPQ bind to streptavidin with a higher affinity. A screening of phage libraries followed by chemical preparation of sequences indicates that a structural-based design can be used along with a chemical process for the design and development of drugs.
Details
- ISSN :
- 00062960
- Volume :
- 34
- Issue :
- 47
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.18163158