Suppression of meal size by intestinal nutrients is eliminated by celiac vagal deafferentation

The effects of intraduodenal infusions of 10 nutrients on the food intake of rats with selective deafferentations of the celiac branches of the vagus nerve were observed to identify the location of the receptors involved in the negative feedback loop that controls food intake. The results show that vagal celiac afferent nerves are involved in the suppression of food intake by preabsorptive detection of certain nutrients.