Select dietary fatty acids attenuate cardiopulmonary dysfunction during acute lung injury in pigs

Enteral diets containing borage and fish oils were fed to pigs with cardiopulmonary dysfunction following endotoxin-induced acute lung injury to determine if n-3 and gamma-linolenic acid (gamma-LA) can be used in the management of acute lung injury. The results show that dietary eicosapentaenoic acid and gamma-LA improved oxygen delivery and gas exchange, possibly by modifications of eicosanoid synthesis combined with an increase in cardiac output and reduction of pulmonary vascular resistance.