Conditional mouse osteosarcoma, dependent on p53 and potentiated by loss of Rb, mimics the human disease

Authors :: Walkley, Carl R.
Qudsi, Rameez
Sankaran, Vijay G.
Perry, Jennifer A.
Gostissa, Monica
Roth, Sanford I.
Rodda, Stephen J.
Snay, Erin
Dunning, Patricia
Fahey, Frederic H.
Alt, Frederich W.
McMahon, Andrew P.
Orkin, Stuart H.
Source :: Genes & Development. June 15, 2008, Vol. 22 Issue 12, 1662-1672
Publication Year :: 2008
Abstract: The generation and characterization of a genetically engineered mouse model in which all animals develop short latency malignant osteosarcoma is described. The model based on osteoblast-restricted deletion of p53 and pRb showed strong similarities between murine osteosarcoma and human osteosarcoma could be used to address the molecular genetics of osteosarcoma and develop novel therapeutic strategies.

Subjects :: Genetically modified mice -- Models
Osteosarcoma -- Genetic aspects
Mouse leukemia complex -- Research
Gene mutations -- Analysis
Biological sciences

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