The role of the chromatin remodeler Mi-2[beta] in hematopoietic stem cell self-renewal and multilineage differentiation

Authors :: Yoshida, Toshimi
Hazan, Idit
Jiangwen Zhang
Ng, Samuel Y.
Taku Naito
Snippert, Hugo J.
Heller, Elizabeth J.
Xiaoqing Qi
Lawton, Lee N.
Williams, Christine J.
Georgopoulos, Katia
Source :: Genes & Development. May 1, 2008, Vol. 22 Issue 9, 1174-1189
Publication Year :: 2008
Abstract: Study conducted presents the first evidence that the SNF2-like ATPase Mi-2[beta] of the Nucleosome Remodeling Deacetylase (NuRD) complex is required for maintenance of and multilineage differentiation in the early hematopoietic hierarchy. It is observed that Mi-2[beta] provides the hematopoietic system with immune cell capabilities and an extensive regenerative capacity.

Subjects :: Autopoiesis -- Research
Chromatin -- Research
Hematopoietic system -- Analysis
Somatic cells -- Research
Biological sciences

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