Glucose-induced, cyclic-AMP-independent signalling pathway for activation of neutral trehalase in the fission yeast Schizosaccharomyces pombe

A cyclic-adenylic acid (cAMP) signal and cytoplasmic neutral trehalase activation in derepressed growing cells of Schizosaccharomyces pombe is observed by adding glucose. The trehalase activation requires a cAMP-dependent protein kinase (PKA1). During the presence of a cAMP-independent protein kinase, the activation occurs via a glucose- induced phosphorylation mechanism. Trehalase is the natural substrate for PKA1 and is a target for at least another protein kinase of the fission yeast.