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Different effects of histamine H1 and H2 stimulation on left ventricular contractility in pigs
- Source :
- The American Journal of Physiology. Sept, 1995, Vol. 269 Issue 3, pH959, 6 p.
- Publication Year :
- 1995
-
Abstract
- Contractility of the left ventricle increases at higher doses of histamine and at low doses of histamine, left ventricular contractility decreases. The stimulation of the H2-receptor is responsible for the higher rate of contraction. The stimulation of H1-receptor decreases the left ventricular contractility. The shift of the end-systolic pressure-volume relation is a measurement of the change in the left ventricular contractile function. The end-systolic pressure-volume relation is largely increased by the injection of low doses of histamine.
- Subjects :
- Histamine -- Research
Heart ventricles -- Research
Biological sciences
Subjects
Details
- ISSN :
- 00029513
- Volume :
- 269
- Issue :
- 3
- Database :
- Gale General OneFile
- Journal :
- The American Journal of Physiology
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.18061764