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Different effects of histamine H1 and H2 stimulation on left ventricular contractility in pigs

Authors :
Cooper, D. James
Schellenberg, R. Robert
Walley, Keith R.
Source :
The American Journal of Physiology. Sept, 1995, Vol. 269 Issue 3, pH959, 6 p.
Publication Year :
1995

Abstract

Contractility of the left ventricle increases at higher doses of histamine and at low doses of histamine, left ventricular contractility decreases. The stimulation of the H2-receptor is responsible for the higher rate of contraction. The stimulation of H1-receptor decreases the left ventricular contractility. The shift of the end-systolic pressure-volume relation is a measurement of the change in the left ventricular contractile function. The end-systolic pressure-volume relation is largely increased by the injection of low doses of histamine.

Details

ISSN :
00029513
Volume :
269
Issue :
3
Database :
Gale General OneFile
Journal :
The American Journal of Physiology
Publication Type :
Academic Journal
Accession number :
edsgcl.18061764