Serotonin enhances gastric acid response to TRH analogue in dorsal vagal complex through 5-HT2 receptors in rats

Exogenous serotonin (5-HT) increases the gastric acid response activated by microinjection of a stable thyrotropin releasing hormone (TRH) analogue in the dorsal vagal complex (DVC) of rats. Results of a study indicate that a receptor belonging to 5HT2 family is responsible for mediation in 5-HT action. A promoting interaction was also observed between endogenous TRH and 5-HT in DVC at the 5-HT2 receptors in the gastric acid response to excitation of Rpa neurons.