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Association of loss-of-function mutations in the ABCA1 gene with high-density lipoprotein cholesterol levels and risk of ischemic heart disease

Authors :
Frikke-Schmidt, Ruth
Stene, Maria C.A.
Nordestgaard, Borge G.
Sethi, Amar A.
Remaley, Alan T.
Schnohr, Peter
Grande, Peer
Tybjaerg-Hansen, Anne
Source :
JAMA, The Journal of the American Medical Association. June 4, 2008, Vol. 299 Issue 21, p2524, 9 p.
Publication Year :
2008

Abstract

A study to examine whether the mutated gene ABCA1 was responsible for the increased risk of ischemic heart disease (IHD) and enhanced levels of high-density lipoprotein (HDL) cholesterol levels is conducted. Results reveal that the mutated gene did not have any effect of increased risk of IHD and HDL.

Details

Language :
English
ISSN :
00987484
Volume :
299
Issue :
21
Database :
Gale General OneFile
Journal :
JAMA, The Journal of the American Medical Association
Publication Type :
Academic Journal
Accession number :
edsgcl.180495120