NaCl injections in brain induce natriuresis and blood pressure responses sensitive to ANG II AT1 receptors

Natriuretic and blood pressure changes due to hypertonic saline injections in brain are controlled by a central angiotensinergic mechanism. There is a concentration-dependent increase of renal sodium excretion after bolus injections of hypertonic saline. There is a notable increase in mean arterial blood pressure (MAP) after injection of two highest saline concentrations. High saline concentration in cerebrospinal fluid causes angiotensin II-controlled natriuresis.