A DFT-D investigation of the mechanisms for activation of the wild-type and S810L: mutated mineralocorticoid receptor by steroid hormones

A study was conducted to determine the relative magnitudes of the various interactions that occur between different steroid hormones and residues found within the binding pocket of mutated mineralocorticoid (MR). The results obtained revealed a strong hydrogen bond between progesterone and Thr945 and a relatively strong hydrophobic interaction between progesterone and Asn770.