Amyloid fiber formation and membrane disruption are separate processes localized in two distinct regions of IAPP, the type-2-diabetes-related peptide

The various different processes taking place in the type-2-diabetes-related peptide, IAPP (Islet Amyloid Polypeptide) are discussed. The analysis shows that the sequences that are responsible for the formation of amyloid fiber and membrane disruption occur independently in two distinct regions of the peptide.