A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with Lumbar-disc herniation

Authors :: Hirose, Yuichiro
Chiba, Kazuhiro
Karasugi, Tatsuki
Nakajima, Masahiro
Kawaguchi, Yoshiharu
Mikami, Yasuo
Furuichi, Tatsuya
Mio, Futoshi
Miyake, Atsushi
Miyamoto, Takeshi
Ozaki, Kouichi
Takahashi, Atsushi
Mizuta, Hiroshi
Kubo, Toshikazu
Kimura, Tomoatsu
Tanaka, Toshihiro
Toyama, Yoshiaki
Ikegawa, Shiro
Source :: American Journal of Human Genetics. May, 2008, Vol. 82 Issue 5, p1122, 8 p.
Publication Year :: 2008
Abstract: The associations between the functional polymorphism in thrombospondins (THBSs) and lumbar-disc herniation (LDH), a common muscoskeletal disease are discussed. THBS2 is shown to highly affect alternative splicing and the binding of matrix metalloproteinases (MMPs) in the Japanese populations.

Subjects :: Genetic polymorphisms -- Analysis
Metalloenzymes -- Research
Bones -- Abnormalities
Bones -- Genetic aspects
Population genetics -- Genetic aspects
Biological sciences

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