Global histone acetylation induces functional genomic reorganization at mammalian nuclear pore complexes

A study was conducted to examine the correlation between the mammalian nuclear pore and the human genome by generating high-resolution, chromosome-wide binding maps of human nucleoporin 93 (Nup93) in the presence and absence of a potent histone deacetylase inhibitor (HDACI). Results showed that inhibition of HDACs lead to significant changes in genomic organization, recruiting regions of transcriptional regulation to mammalian nuclear pore complexes.