Peptide aldehyde inhibitors of hepatitis A virus 3C proteinase

Picornaviral 3C proteinases have a structure that is a hybrid between thiol proteinase of the papain family and the mammalian serine proteinases. The picornaviral family consists of a group of thiol proteinases that cause the cleaving of viral polyproteins into their component proteins. The picornaviral 3C enzymes catalyze peptide-bond cleavage and the structures of hepatitis A virus (HAV) and human rhinovirus (HRV) indicate that these enzymes are different from the papain family. Peptide-aldehyde is an inhibitor of HAV 3C.