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Structural aligments of (+)- and (-)-trans-anti-benzo(a)pyrene-dG adducts positioned at a DNA template-primer function
- Source :
- Biochemistry. Nov 21, 1995, Vol. 34 Issue 46, p15334, 17 p.
- Publication Year :
- 1995
-
Abstract
- The structural characteristics of (+) and (-)-trans-anti-benzo(a)-pyrene-dG adducts located at the junction site of single-strand/duplex 13/9-mer sequence were determined. The analyses involve the use of MNR spectrometry in combination with molecular mechanics calculations. The results showed that the modified 13-mer strand mimics the template strand, while the complementary 9-mer strand mimics a primer which extends from the 3'-end of the template toward the 5'-end up to the base preceding the modified guanine.
- Subjects :
- Benzopyrene -- Research
DNA -- Research
Biological sciences
Chemistry
Subjects
Details
- ISSN :
- 00062960
- Volume :
- 34
- Issue :
- 46
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.17828231