High-fat feeding alters the response of rat PDH complex to acute changes in glucose and insulin

The activity of the pyruvate dehydrogenase complex (PDHC), as an indicator of glucose oxidation in tissues of controls, showed that changes in PDHC activity induced significantly short-term increases in plasma insulin within the physiological range in insulin resistant fat-fed rats. It is proven that the regulation of intracellular glucose oxidation depends on the local intracellular fatty acid metabolism.