A linear B-cell epitope on the class 3 outer-membrane protein of Neisseria meningitidis recognized after vaccination with the Norwegian group B outer-membrane vesicle vaccine

The Norwegian serogroup B meningococcal outer-membrane vesicle (OMV) vaccine initiates the release of antibiotics specific for human linear BCE present in the serotype 15 protein loop. Synthetic peptides of class 3 OMP were prepared on pins and screened with serum of Norwegian adolescents immunized with meningococcal serogroup B OMV vaccine. There was an increase in the number of IgG antibodies apart from heterogeneity in IgG concentration.