Whole-genome maps of USF1 and USF2 binding and histone H3 acetylation reveal new aspects of promoter structure and candidate genes for common human disorder

The deoxyribonucleic acid (DNA) binding profiles of upstream stimulatory factors 1 and 2 (USF1 and USF2) and acetylated histone H3 (H3ac) in a liver cell line were mapped for the whole human genome. Results reveal new human promoter architecture as well as genes with a bidirectional conformation and a set of candidate genes for common metabolism disorders.