Maternal periodontal disease, systemic inflammation, and risk for preeclampsia

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajog.2007.12.002 Byline: Michael Ruma (a), Kim Boggess (a), Kevin Moss (b), Heather Jared (b), Amy Murtha (d), James Beck (b), Steven Offenbacher (c) Keywords: C-reactive protein; inflammation; periodontal disease; preeclampsia; pregnancy Abstract: Maternal periodontal disease, a chronic oral infectious and inflammatory disorder, is associated with an increased risk for preeclampsia. Our objective was to determine the relationship between maternal periodontal disease, maternal systemic inflammation, and the development of preeclampsia. Author Affiliation: (a) Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC (b) Department of Dental Ecology, University of North Carolina at Chapel Hill School of Dentistry, Chapel Hill, NC (c) Department of Periodontology, University of North Carolina at Chapel Hill School of Dentistry, Chapel Hill, NC (d) Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC. Article History: Received 19 January 2007; Revised 3 December 2007; Accepted 6 December 2007 Article Note: (footnote) Cite this article as: Ruma M, Boggess K, Moss K, et al. Maternal periodontal disease, systemic inflammation, and risk for preeclampsia. Am J Obstet Gynecol 2008;198:389.e1-389.e5. , Supported by NIDCR grant R01-DE012453, NCRR RR00046, and NICHD K08HD043284, RO1HD26652, and K12HD01441.