Time-resolved infrared spectroscopy of thiopeptide isomerization and hydrogen-bond breaking

Authors :: Cervetto, Valentina
Pfister, Rolf
Helbing, Jan
Source :: Journal of Physical Chemistry B. March 20, 2008, Vol. 112 Issue 11, 3540-3544
Publication Year :: 2008
Abstract: A combination of UV-pump-IR-probe spectroscopy is used to study the photoisomerization dynamics of the protected tetrathioxopeptide Boc-Ala-Gly(=S)-Ala-Aib-OMe. The findings from the study provide insight into isomerization of the thioamide bond after excitation to the [pi]-[pi]* ([S.sub.2]) electronic excited state which phototriggers the breaking of the hydrogen bond.

Subjects :: Infrared spectroscopy -- Analysis
Isomerization -- Analysis
Hydrogen bonding -- Research
Polypeptides -- Structure
Polypeptides -- Optical properties
Polypeptides -- Spectra
Chemicals, plastics and rubber industries

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