ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme [Q.sub.10] deficiency

The significance and the role of the ancestral kinase, aarF-domain-containing kinase 3 gene (ADCK3) in the ubiquinone synthesis are discussed. ADCK3 mutations are found to regulate the production of ATP, hence leading to the deficiency of coenzyme [Q.sub.10].