A functional polymorphism in COL11A1, which encodes the [alpha]1 chain of type XI collagen, is associated with susceptibility to lumbar disc herniation

Authors :: Mio, Futoshi
Chiba, Kazuhiro
Hirose, Yuichiro
Kawaguchi, Yoshiharu
Mikami, Yasuo
Oya, Takeshi
Mori, Masaki
Kamata, Michihiro
Matsumoto, Morio
Ozaki, Kouichi
Tanaka, Toshihiro
Takahashi, Atsushi
Kubo, Toshikazu
Kimura, Tomoatsu
Toyama, Yoshiaki
Ikegawa, Shiro
Source :: American Journal of Human Genetics. Dec, 2007, Vol. 81 Issue 6, p1271, 7 p.
Publication Year :: 2007
Abstract: COL11A1, type XI collagen genes is identified as a gene for lumbar disc herniation (LDH) disease. It was observed that COL11A1 was highly expressed in intervertebral disc (IVD) but its expression was decreased in the IVD of patients with LDH.

Subjects :: Gene expression -- Research
Single nucleotide polymorphisms -- Research
Intervertebral disk displacement -- Genetic aspects
Intervertebral disk -- Hernia
Intervertebral disk -- Genetic aspects
Biological sciences

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