RAD51 135G C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies

Authors :: Antoniou, Antonis C.
Sinilnikova, Olga M.
Simard, Jacques
Leone, Melanie
Dumont, Martine
Neuhausen, Susan L.
Struewing, Jeffery P.
Stoppa-Lyonnet, Dominique
Barjhoux, Laure
Hughes, David J.
Coupier, Isabelle
Belotti, Muriel
Lasset, Christine
Bonadona, Valerie
Bignon, Yves-Jean
Rebbeck, Timothy R.
Wagner, Theresa
Lynch, Henry T.
Domchek, Susan M.
Nathanson, Katherine L.
Garber, Judy E.
Weitzel, Jeffrey
Narod, Steven A.
Tomlinson, Gail
Godwin, Andrew
Source :: American Journal of Human Genetics. Dec, 2007, Vol. 81 Issue 6, p1186, 15 p.
Publication Year :: 2007
Abstract: The article examines RAD51 135 G C polymorphism (rs1801320) with breast cancer risk among BRCA2 female mutation carriers from 19 studies. RAD51 gene is found to be reliable as a modifier of risk among BRCA2 mutation carriers.

Subjects :: Breast cancer -- Genetic aspects
Breast cancer -- Risk factors
Mutation (Biology) -- Research
Polymerase chain reaction -- Usage
Biological sciences

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