Molecular dynamics simulation of the structure, dynamics, and thermostability of the RNA hairpins uCACGg and cUUCGg

The structure, dynamics, and thermal stability of the structurally similar 14-mer RNA hairpins uCACGg and cUUCGg are studied by using replica-exchange molecular dynamics simulations. The two RNA hairpins exhibited similar structures at room temperature, but the UUCG loop was found to be more flexible than the CACG loop.