Ca2+ depletion prevents anoxic death of hepatocytes by inhibiting mitochondrial permeability transition

Authors :: Pastorino, John G.
Snyder, Jack W.
Hoek, Jan B.
Farber, John L.
Source :: The American Journal of Physiology. March, 1995, Vol. 268 Issue 3, pC676, 10 p.
Publication Year :: 1995
Abstract: The killing of rat hepatocytes by rotenone and anoxia is arrested by the removal of Calcium ions from the culture medium or treating the hepatocytes with intracellular Calcium chelators. The process does not prevent the depletion of ATP and the mitochondiral membrane potential loss.

Subjects :: Cyclosporine -- Research
Cyanides -- Research
Esters -- Physiological aspects
Biological sciences

Tools