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Large-scale motions and electrostatic properties of furin and HIV-1 protease

Authors :
Carnevale, V.
Raugei, S.
Micheletti, C.
Carloni, P.
Source :
Journal of Physical Chemistry A. Dec 13, 2007, Vol. 111 Issue 49, 12327-12332
Publication Year :
2007

Abstract

The two members of serine and aspartic proteases complexes with a peptide substrate are compared. Furin and HIV-1 protease complexes are characterized by a different interplay of electrostatics and conformational fluctuations in spite of some chemical analogies in the reaction mechanism.

Subjects

Subjects :
Golgi apparatus -- Research
HIV (Viruses) -- Research
Electrostatics -- Analysis
Molecular dynamics -- Analysis
Chemicals, plastics and rubber industries

Details

Language :
English
ISSN :
10895639
Volume :
111
Issue :
49
Database :
Gale General OneFile
Journal :
Journal of Physical Chemistry A
Publication Type :
Academic Journal
Accession number :
edsgcl.172996602

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