Calcium-dependent glutamate release during neuronal development and synaptogenesis: different involvement of omega-agatoxin IVA- and omega-conotoxin GVIA-sensitive channels

Authors :: Verderio, Claudia
Coco, Silvia
Fumagalli, Guido
Matteoli, Michela
Source :: Proceedings of the National Academy of Sciences of the United States. July 3, 1995, Vol. 92 Issue 14, p6449, 5 p.
Publication Year :: 1995
Abstract: The release of glutamate by hippocampal neurons by a calcium dependent mechanism is independent of the formation and maturation of synaptic contacts. The exocytic-endocytic recycling of synaptic vesicles is Ca2+ dependent. In the development stages, the omega-agatoxin IVA- and omega-conotoxin GVIA control the secretion of neurotransmitter, glutamate. A change in the subtype of calcium channels is directed by the neuronal differentiation and synaptic contacts maturation.

Subjects :: Glutamate -- Analysis
Developmental neurology -- Observations
Hippocampus (Brain) -- Observations
Science and technology

ISSN :: 00278424
Volume :: 92
Issue :: 14
Database :: Gale General OneFile
Journal :: Proceedings of the National Academy of Sciences of the United States
Publication Type :: Academic Journal
Accession number :: edsgcl.17190621

Tools