Staphylococcal enterotoxins bind H-2D(super b) molecules on macrophages

The binding of staphylococcal enterotoxin A and B (SEA and SEB respectively) to the alpha 2 domain of the H-2D(super b) molecule causes biological activity that is physiologically important. Major histocompatability complex class II (MHC II) molecules are receptors for superantigens with two binding sites outside the peptide site. The binding of staphylococcal enterotoxins to C2D macrophages is inhibited by two monoclonal antibodies HB36 and TIB126.