Alloantigen priming induces a state of unresponsiveness in human umbilical cord blood T cells

Authors :: Risdon, Grant
Gaddy, Jay
Horie, Masato
Broxmeyer, Hal E.
Source :: Proceedings of the National Academy of Sciences of the United States. March 14, 1995, Vol. 92 Issue 6, p2413, 5 p.
Publication Year :: 1995
Abstract: Analysis of alloreactivity in human adult and umbilical cord blood T cells in mixed leukocyte cultures upon exposure to an allogeneic lymphoblastoid line expressing costimulatory molecules shows that cord blood T cells exhibit unresponsiveness subsequent to alloantigen priming. Adding exogenous interleukin 2 does not avert unresponsiveness, which is long-lasting and maintained by anergy and activity of CD8+ suppressor cells.

Subjects :: Fetal blood -- Analysis
T cells -- Research
Reactivity (Chemistry) -- Analysis
Science and technology

ISSN :: 00278424
Volume :: 92
Issue :: 6
Database :: Gale General OneFile
Journal :: Proceedings of the National Academy of Sciences of the United States
Publication Type :: Academic Journal
Accession number :: edsgcl.17102290

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